Product: Ibutamoren (MK 677)
Manufacturer: Magnus Pharmaceuticals
Pack: 30 cap
Steroid cycle: growth hormone
Ibutamoren, more commonly known as “MK-677”, is the most powerful and potent orally administered growth hormone secretagogue, when it comes to selective androgen receptor modulators, also known as “SARMs”. Simply put, a secretagogue is a substance that chemically signals the pituitary gland to increase secretion of growth hormone Ibutamoren MK 677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections, nor does it have similar side effects. Originally developed by Reverse Pharmacology, Ibutamoren MK 677 aimed to combat conditions like muscle wasting, obesity, osteoporosis, and, oddly enough, the treatment of elderly hip fracture patients.
Ibutamoren MK 677 Magnus Pharmaceuticals is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is a term for a substance that chemically signals for the pituitary gland to secrete growth hormone. In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed with an aim to combat such conditions as muscle wasting, obesity, and osteoporosis. It was also targeted towards the treatment of elderly hip fracture patients, so there is a myriad of studies done on safety.
How Ibutamoren MK 677 Magnus Pharmaceuticals works:
Growth hormone pulse intensity can be increased through 4 possible mechanisms:
Increasing GHRH (growth hormone releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
Ibutamoren MK 677 was found to work through all four of these mechanisms.
After ingestion, Growth Hormone (GH) was shown to increase dose-dependently, at doses starting at 5 milligrams (mg) a day.
In a study on its effects on catabolic states, a once daily oral dose of 25mgs Magnus Pharmaceuticals was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this Magnus Pharmaceuticals dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
Trials testing the effects of this GHS on fighting obesity showed an increase in lean body mass, but neither total nor visceral adipose tissue was affected. This study gave subjects 25mgs of Magnus Pharmaceuticals per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. The increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage directly.
A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. Magnus Pharmaceuticals can help with injury recovery during your cycle.
In addition, some studies also suggest that an increased immune system response was caused by Ibutamoren MK 677, meaning it boosts the immune system to a degree.
Elevated growth hormone has a literally endless list of benefits to the human body, why do you think everyone tries to get their hands on HGH? That’s why Ibutamoren MK 677 is so effective, it increases Growth Hormone and IGF-1 levels.
As the studies show, Ibutamoren MK 677 can be used for a number of reasons from growing muscle mass, to getting shredded. It does not compete with the levels of growth hormone one can get from exogenously administered HGH, so you can use it with hgh cycles. In fact, by using Ibutamoren MK 677, you can easily get amazing increases of your own natural growth hormone pulses without having to deal with annoying and painful daily HGH injections. It’s like using HGH without having to inject daily.
In fact, many users report growing up to 6 lbs of lean muscle mass in 8 weeks of IGF-1 only cycles. That’s an amazing result, but injecting IGF-1 daily is painful, costly and frustrating. Now, there is an oral-only alternative.
25 mg Ibutamoren MK 677
MR-677, Ibutamoren MK 677, Ibutamoren
In the bodybuilding and athletic worlds, Ibutamoren MK 677 is used as a side-effect free alternative to steroids. Some of the usual side effects that go with elevated GH levels such as numb hands, some lethargy, as well as slightly increased appetite have been reported with the use of Ibutamoren MK 677. Interestingly, during prolonged administration, both IGF-1 and GH were increased with no increase in cortisol.
Some anecdotal evidence suggested there was a temporary small increase in prolactin when beginning administration, so individuals who are very prone to prolactin side effect may want to incorporate a short schedule of HCGenerate ES to prevent problems. I want to stress, this is only an issue for guys who are extremely prone to prolactin sides, which is usually 1% of users. How do you know if you’re prone to prolactin sides? If you get gynecomastia from taking trenbolone, you’re prone to prolactin sides.
The most common doses of Ibutamoren MK 677 range between 5-25mgs per day. In some cases, we’ve seen doses upwards of 50mgs per day, but these are few and far between and didn’t result in exponential benefits above the recommended top-end dosage of 20-25mgs Ibutamoren MK 677 per day.